The College on Problems of Drug Dependence (CPDD), formerly the Committee on Problems of Drug Dependence, has been in existence since 1929 and is the longest standing group in the United States addressing problems of drug dependence and abuse. From 1929 until 1976, the CPDD was associated with the National Academy of Sciences, National Research Council. Since 1976, the organization has functioned as an independent body affiliated with other scientific and professional societies representing various disciplines concerned with problems of drug dependence and abuse. In 1991, the CPDD evolved into a membership organization with the new name of College on Problems of Drug Dependence.

CPDD serves as an interface among governmental, industrial and academic communities maintaining liaisons with regulatory and research agencies as well as educational, treatment, and prevention facilities in the drug abuse field. It also functions as a collaborating center of the World Health Organization.