Drug and Alcohol Dependence
Volume 65, Issue 3 , Pages 263-281 , 1 February 2002

Effect of maternal methionine pre-treatment on alcohol-induced exencephaly and axial skeletal dysmorphogenesis in mouse fetuses

  • R Padmanabhan

      Affiliations

    • Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, PO Box 17666, Al Ain, United Arab Emirates
    • Corresponding Author InformationCorresponding author. Tel.: +971-3-703-9494; fax: +971-3-767-2033
  • ,
  • Ahmad Ibrahim

      Affiliations

    • Department of Pediatrics, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
  • ,
  • Abulbari Bener

      Affiliations

    • Department of Community Medicine, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates

Received 15 February 2001 ,Accepted 25 May 2001.

References 

  1. Abel EL, Sokol RJ. Incidence of fetal alcohol syndrome (FAS) and economic impact of FAS-related anomalies. Drug Alcohol. Depend. 1987;19:51–70
  2. Abel EL, Sokol R. A revised conservative estimate the incidence of FAS and its economic impact. Alcohol. Clin. Exp. Res. 1991;14(4):514–524
  3. Armant R, Saunders DE. Exposure of embryonic cells to alcohol: contrasting effects during preimplantation and post implantation development. Semin. Perinatol. 1996;20(2):127–139
  4. Ariyuki F, Higaki K, Yasuda M. Staging of ossification in the supraoccipital bone in pre-term fetuses. Cong. Anom. 1980;20:375–381
  5. Bannigan J, Burke P. Ethanol teratogenicity in mice: a light microscopic study. Teratology. 1982;26:247–254
  6. Becker HC, Diaz-Grandos JL, Randall CL. Teratogenic actions of ethanol in the mouse: a mini review. Pharmacol. Biochem. Behav. 1996;55(4):501–513
  7. Cartwright MM, Smith SM. Increased cell death and reduced neural crest cell numbers in ethanol-exposed embryos: partial basis for the fetal alcohol syndrome. Alcohol. Clin. Exp. Res. 1995;19:378–386
  8. Chang BE, Blader P, Fischer N, Inghan PW, Strahle U. Axial (HNF3β) and retinoic acid receptors are regulators of the zebrafish sonic hedgehog promoter. EMBO J. 1997;16:3955–3964
  9. Chatot CL, Klein NW, Clapper ML, Resor SR, Singer WE, Rusman BS, et al. Human serum teratogenicity studies by rat embryo culture: epilepsy, anticonvulsant drugs and nutrition. Epilepsia. 1984;25:205–216
  10. Chernoff GF. The fetal alcohol syndrome in mice: maternal variables. Teratology. 1980;22:71–75
  11. Chiang C, Litingtung Y, Lee E, Young K, Corden JL, Westphal H, et al. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature. 1996;383:407–413
  12. Clarren SK, Alvord EC, Smith SM, Streissguth AP, Smith DW. Brain malformations related to prenatal exposure to ethanol. J. Pediatr. 1978;92:64–67
  13. Coelho CD, Weber JA, Klein NW, Daniels WG, Hogland TA. Whole rat embryos require methionine for neural tube closure when cultured on cow serum. J. Nutr. 1989;119:1716–1725
  14. Coelho CD, Klein NW. Methionine and neural tube closure in cultured rat embryo: morphological and biochemical analyses. Teratology. 1990;42:437–451
  15. Conlan RA. Retinoic acid and pattern formation in vertebrates. Trend Genet. 1995;11:314–319
  16. Copp AJ. Prevention of neural tube defects: vitamins, enzymes and genes. Curr. Opin. Neurol. 1998;11:97–102
  17. Crandall BF, Corson VL, Goldberg JD, Knight G, Salafsky IS. Folic acid and pregnancy. Am. J. Med. Genet. 1995;55:134–135
  18. Czeizel A, Dudas I. Prevention of first occurrence of neural tube defects by periconceptional vitamin supplementation. N. Engl. J. Med. 1992;327:1831–1835
  19. Daly LE, Kirke PN, Molloy A, Weir DG, Scott JM. Folate levels and neural tube defects. Implications for prevention. JAMA. 1995;274:1698–1702
  20. Davis WL, Crawford LA, Cooper OJ, Farmer GR, Thomas DL, Freeman BL. Ethanol induces the generation of reactive free radicals by neural crest cells in vitro. J. Craniofac. Genet. Dev. Biol. 1990;10:273–277
  21. Diehl AM, Yang SQ, Gote P, Wand GS. Chronic ethanol consumption disturbs G-protein expression and inhibits cyclic AMP-dependent signaling in regenerating rat liver. Hepatology. 1992;16(5):1212–1219
  22. Duester G. A hypothetical mechanism for fetal alcohol syndrome involving ethanol inhibition of retinoic acid synthesis at the alcohol dehydrogenase step. Alcohol. Clin. Exp. Res. 1991;15:568–572
  23. Essein FB, Wannberg S. Methionine but not folic acid or vitamin B12 alters the frequency of neural tube defects in Axd mutant mice. J. Nutr. 1993;123:27–34
  24. Flynn TJ, Friedman L, Black TN, Klein NW. Methionine and iron as growth factors for rat embryos cultured in canine serum. J. Exp. Zool. 1987;244:319–324
  25. Graham JM, Ferm VH. Heat- and alcohol-induced neural tube defects; interactions with folate in a golden hamster model. Pediatr. Res. 1985;19:247–251
  26. Halsted CH, Villanueva J, Chandler CJ, Stabler SP, Allen RH, Muskhelishvili L, et al. Ethanol feeding of micropigs alters methionine metabolism and increases hepatocellular apoptosis and proliferation. Hepatology. 1996;23:497–505
  27. Hannigan JH, Welch RA, Sokol RJ. Recognition of fetal alcohol syndrome and related birth defects. In:  Mendelson JH,  Mello NK editor. Medical Diagnosis and Treatment of Alcoholism. New York: McGraw Hill; 1992;p. 639–667
  28. Hanson DK, Grafton TF. Lack of attenuation of valproic acid-induced effects by folinic acid in rat embryos in vitro. Teratology. 1991;43:575–582
  29. Hanson JW, Jones KL, Smith DW. Fetal alcohol syndrome, experience with 41 patients. JAMA. 1976;235:1458–1460
  30. Herbert V, Zalusky R, Davidson CS. Correlation of folate deficiency with alcoholism and associated macrocytosis, anemia and liver disease. Ann. Intern. Med. 1963;58:977–988
  31. Inouye M. Differential staining of cartilage and bone in fetal mouse skeleton by alcian blue and alizarin red S. Cong. Anom. 1976;16:71–173
  32. Johnson RL, Laufer W, Riddle RD, Tabin C. Ectopic expression of sonic hedgehog alters dorsal-ventral patterning of somites. Cell. 1994;79:1165–1173
  33. Jones KL, Smith DW. Recognition of the fetal alcohol syndrome in early infancy. Lancet. 1973;2:999–1001
  34. Jones KL, Smith DW, Ulleland CN, Streissguth AP. Pattern of malformation in offspring of chronic alcoholic mothers. Lancet. 1973;1:1267–1271
  35. Keir WJ. Inhibition of retinoic acid synthesis and its implication in fetal alcohol syndrome. Alcohol. Clin. Exp. Res. 1991;15:560–564
  36. Kessel M, Gruss P. Homeotic transformations of murine vertebrae and concomitant alterations of Hox codes induced by retinoic acid. Cell. 1991;67:89–104
  37. Kessel M. Respecification of vertebral identities by retinoic acid. Development. 1992;115:487–501
  38. Kirke PN, Molloy AM, Daly LE, Burke H, Weir DG, Scott JM. Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects. Q. J. Med. 1993;86:703–708
  39. Kotch LE, Sulik KK. Experimental fetal alcohol syndrome: proposed pathogenic basis for a variety of associated facial and brain anomalies. Am. J. Med. Genet. 1992;44:168–176
  40. Kotch LE, Sulik KK. Patterns of ethanol-induced cell death in the developing nervous system of mice: neural fold stage through the time of anterior neural tube closure. Int. J. Dev. Neurosci. 1992;10:273–279
  41. Kotch LE, Sulik KK. Superoxide dismutase diminishes teratogenicity of ethanol in mouse whole embryo culture. Teratology. 1992;45(5):509; Abstract
  42. Lemaire L, Kessel M. Gastrulation and homoeobox genes in chick embryos. Mech. Dev. 1997;67:3–16
  43. Lemoine P, Harousseau H, Borteryu JP, Menuet JC. Les enfants de parents alcoholiques: anomalies observe a propos des 127 cas. Quest Medicale. 1968;21:476–482
  44. Martinez-Frias ML, Frias JL, Opitz JM. Errors of morphogenesis and developmental field theory. Am. J. Med. Genet. 1998;76:291–296
  45. Mc Guffin R, Goff P, Holman RS. Effect of diet and alcohol on the development of folate deficiency in the rat. Br. J. Haematol. 1975;31(2):185–192
  46. McMartin KE, Shiao CQ, Collins TD, Redetzki HM. Acute ethanol ingestion by humans and subacute treatment of rats increase urinary folate excretion. Alcohol. 1985;2:473–477
  47. Miller JW, Nadeau MR, Smith J, Smith D, Selhub J. Folate deficiency-induced homocysteinaemia in rats: disruption of S-adenosylmethionine's co-ordinate regulation of homocysteine metabolism. Biochem. J. 1994;298:415–419
  48. Mills JL, McPartlin JM, Kirke PN, Lee YJ, Conley MR, Weir DG. Homocysteine metabolism in pregnancies complicated by neural tube defects. Lancet. 1995;345:149–151
  49. Morrison K, Edwards YH, Lynch SA, Burn J, Hol F, Mariman E. Methionine synthase and neural tube defects. J. Med. Genet. 1997;34:958
  50. MRC Vitamin Study Research Group, 1991. Prevention of neural tube defects: results of the Medical Research Council vitamin study. Lancet 338, 131–137.
  51. Muldoon RT, McMartin KE. Ethanol acutely impairs the renal conservation of 5-methyltetrahydrofolate in the isolated perfused rat kidney. Alcohol. Clin. Exp. Res. 1994;18:333–339
  52. Nakatsuji N, Johnson KE. Effects of ethanol on the primitive streak stage mouse embryos. Teratology. 1984;29:369–375
  53. Norusis, M.J., SPSS inc. SPSS/PC+ for Windows, Base System and Advanced Statistic User's Guide, Window Version 10.0, Chicago, IL, 1996.
  54. O'Rahilly R, Muller F. Interpretation of some median anomalies as illustrated by cyclopia and symmelia. Teratology. 1989;40:409–421
  55. Opitz JM, Gilbert EF. CNS anomalies and the midline as a developmental field. Am. J. Med. Genet. 1982;12:443–455
  56. Opitz, J.M., 1993. Blastogenesis and the “primary field” in human development. In: Opitz, J.M., Paul, N.W. (Eds.), Blastogenesis – Normal and Abnormal. Birth Defect Orig. Art. Ser., vol. 29, pp. 3–37.
  57. Ou CY, Stevenson RE, Brown VK, Schwartz CE, Allen WP, Khoury MJ, et al. 5,10 Methylenetetrahydrofolate reductase genetic polymorphism as risk factor for neural tube defects. Am. J. Med. Genet. 1996;63:610–614
  58. Padmanabhan R. Histological and histochemical changes of placenta in fetal alcohol syndrome due to maternal administration of acute doses of ethanol in the mouse. Drug Alcohol. Depend. 1985;16:229–239
  59. Padmanabhan R, Muawad WMRA. Exencephaly and axial skeletal dysmorphogenesis induced by acute doses of ethanol in mouse fetuses. Drug Alcohol. Depend. 1985;16:215–227
  60. Padmanabhan R, Pallot DJ. Aspirin-alcohol interaction in the production of cleft palate and limb malformations in TO mouse. Teratology. 1995;51:404–417
  61. Padmanabhan R, Sreenathan RN, Singh S. Studies on the lethal and teratogenic effects of acetaldehyde in the rat. Cong. Anom. 1983;23:13–23
  62. Padmanabhan R, Hameed MS, Sugathan TN. Effects of acute doses of ethanol on pre- and postnatal development in the mouse. Drug Alcohol. Depend. 1984;14:197–206
  63. Padmanabhan R, Wasfi I, Craigmyle MB. Neural tube and axial skeletal defects in TO mouse fetuses: effect of maternal exposure to ethanol and aspirin. Teratology. 1992;46:27; Abstract
  64. Padmanabhan R, Wasfi IA, Craigmyle MB. Effect of pre-treatment with aspirin on the neural tube defects induced by maternal exposure to alcohol in the TO mouse fetuses. Drug Alcohol. Depend. 1994;36:175–186
  65. Park WK, Kim S. Protein methylation. Science. 1978;174:114–119
  66. Polache A, Martin-Algara RV, Gueri C. Effects of chronic consumption on enzyme activities and active methionine absorption in the small intestine of pregnant rats. Alcohol. Clin. Exp. Res. 1996;20(7):1237–1242
  67. Pullarkart RK. Hypothesis: prenatal ethanol-induced birth defects and retinoic acid. Alcohol. Clin. Exp. Res. 1991;15:565–567
  68. Randall CL, Ekbald U, Anton RF. Perspectives on the pathophysiology of fetal alcohol syndrome. Alcohol. Clin. Exp. Res. 1990;14:807–812
  69. Rawat AK. Effect of maternal ethanol consumption on fetal and neonatal rat hepatic protein synthesis. Biochem. J. 1976;160:653–661
  70. Roessler E, Belloni E, Gaudenz K, Vargas F, Scherer SW, Tsui LC, et al. Mutations in the C-terminal domain of Sonic hedgehog cause holoprosencephaly. Hum. Mol. Genet. 1997;6(11):1847–1853
  71. Rosenquist TH, Ratashak SA, Selhub J. Homocyteine induces congenital defects of the heart and neural tube: effect of folic acid. Proc. Natl. Acad. Sci. 1996;93:15227–15232
  72. Ross AJ, Ruiz-Perez V, Wang Y, Hagan DM, Scherer S, Lynch SA, et al. A homeobox gene, HLXB9, is the major locus for dominantly inherited sacral agenesis. Nat. Genet. 1998;20:358–361
  73. Sanders EJ, Cheung E, Mahmud E. Ethanol treatment inhibits mesoderm cell spreading in the gastrulating chick embryo. Teratology. 1987;36:209–216
  74. Schenker S, Becker HC, Randall CL, Philips DK, Baskin GS, Henderson GI. Fetal alcohol syndrome: current status of pathogenesis. Alcohol. Clin. Exp. Res. 1990;14:635–647
  75. Scott, J.M., Weir, D.G., 1981. The methyl folate trap. In: Munro, I., Fox, D., Sharp, D. (eds.), The Lancet, vol. 2, pp. 337–340.
  76. Shetty AK, Phillips DE. Effects of prenatal ethanol exposure on the development of Bergmann glia and astrocytes in the cerebellum: an immunohistochemical study. J. Comp. Neurol. 1992;321:19–32
  77. Shibly IA, Pennington SN. Metabolic and mitotic changes associated with fetal alcohol syndrome. Alcohol Alcohol. 1997;31(4):423–434
  78. Smith IE, Coles CD. Multilevel intervention for prevention of fetal alcohol syndrome and effects of prenatal alcohol exposure. Recent. Dev. Alcohol. 1991;9:165–180
  79. Spackman DH, Stein WH, Moore S. Automatic recording apparatus for use in the chromatography of amino acids. Anal. Chem. 1958;30:1190
  80. Spagnolo A. Teratogenesis of alcohol. Ann. Ist Super. Sanita. 1993;29(1):89–96
  81. Steegers-Theunissen RPM, Boers GHJ, Trijbels FJM, Finkelstein JD, Blom HJ, Thomas CMG, et al. Maternal hyperhomocysteinemia: a risk factor for neural tube defects. Metabolism. 1994;43(12):1475–1480
  82. Sterz H, Lehmann H. A critical comparison of the free hand razor blade dissection method according to Wilson with an in situ sectioning method for rat fetuses. Terat. Carcin. Mutagen. 1985;5:347–354
  83. Streissguth AP, Landesman-Dwyer S, Martin J, Smith DW. Teratogenic effects of alcohol in humans and animals. Science. 1980;209:353–361
  84. Sulik KK, Lauder JM, Dehart DB. Brain malformations in prenatal mice following acute maternal ethanol administration. Int. J. Dev. Neurosci. 1984;2:203–214
  85. Tamura T, Halsted CH. Folate turnover in chronically alcoholic monkeys. J. Lab. Clin. Med. 1983;101:623–628
  86. Trembath D, Sherbondy AL, Vandyke DC, Shaw GM, Todoroff K, Lammer EJ, et al. Analysis of select folate pathway genes, PAX3, and human T in a Midwestern neural tube defect population. Teratology. 1999;59:331–341
  87. Twal WO, Zile MH. Retinoic acid reverses ethanol-induced cardiovascular abnormalities in quail embryos. Alcohol. Clin. Exp. Res. 1997;26:1137–1143
  88. Van der Put NMJ, van der Molen EF, Kluijtmans LAJ, Heil SG, Trijbels JMF, Eskes TKAB, et al. Sequence analysis of the coding region of human methionine synthase: relevance to hyperhomocysteineamia in neural tube defects and vascular disease. Q. J. Med. 1997;90:511–517
  89. Waldman HB. Fetal alcohol syndrome and the realities of our time. J. Dent. Child. 1989;56:435–437
  90. Walker D, Barnes D, Zornetzer S, Hunter B, Kubanis B. Neuronal loss in hippocampus induced by prolonged ethanol consumption in rats. Science. 1980;209:711–713
  91. West JR, Goodlett CR, Brandt JP. New approaches to research on the long term consequences of prenatal exposure to alcohol. Alcohol. Clin. Exp. Res. 1990;14:684–689
  92. Whitehead AS, Gallagher P, Mills JL, Kirke PN, Burke H, Molloy AM, et al. A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects. Q. J. Med. 1995;88:763–766
  93. Wilson JG. Environment and Birth Defects. New York: Academic Press; 1973;
  94. Zachman RD, Grummer MA. The interaction of ethanol and vitamin A as potential mechanism for the pathogenesis of fetal alcohol syndrome. Alcohol. Clin. Exp. Res. 1998;22(7):1544–1556
  95. Zajac CS, Abel EL. Animal models of prenatal alcohol exposure. Int. J. Epidemiol. 1992;21(4):S24–S32 Suppl. 1

PII: S0376-8716(01)00173-9

doi: 10.1016/S0376-8716(01)00173-9

Drug and Alcohol Dependence
Volume 65, Issue 3 , Pages 263-281 , 1 February 2002