Drug and Alcohol Dependence
Volume 88 , Pages S24-S30 , May 2007

Developing adaptive treatment strategies in substance abuse research

  • Susan A. Murphy

      Affiliations

    • University of Michigan, Institute for Social Research, 426 Thompson St., Ann Arbor, MI 48106-1248, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 734 763 5046; fax: +1 734 763 4676.
  • ,
  • Kevin G. Lynch

      Affiliations

    • University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104-6178, USA
  • ,
  • David Oslin

      Affiliations

    • University of Pennsylvania, Geriatric and Addiction Psychiatry, 3535 Market Street, Room 3002, Philadelphia, PA 19104, USA
  • ,
  • James R. McKay

      Affiliations

    • University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104-6178, USA
  • ,
  • Tom TenHave

      Affiliations

    • University of Pennsylvania, School of Medicine, 607 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104-6021, USA

Received 30 March 2006 ,Revised 17 September 2006 ,Accepted 18 September 2006.

References 

  1. Albert JM, Yun H. Statistical advances in AIDS therapy trials. Stat. Methods Med. Res. 2001;10:85–100
  2. Altfeld M, Walker BD. Less is more? STI in acute and chronic HIV-1 infection. Nat. Med. 2001;7:881–884
  3. Breslin FC, Sobell MB, Sobell LC, Cunningham JA, Sdao-Jarvie K, Borson D. Problem drinkers: evaluation of a stepped-care approach. J. Subst. Abuse. 1999;10(3):217–232
  4. Brooner RK, Kidorf M. Using behavioral reinforcement to improve methadone treatment participation. Sci. Pract. Perspect. 2002;1:38–48
  5. Brown BS. Drug use—chronic and relapsing or a treatable condition?. Subst. Use Misuse. 1998;33(12):2215–2520
  6. Byar DP. Why data bases should not replace randomized clinical trials. Biometrics. 1980;36(2):337–342
  7. Byar DP. The use of data bases and historical controls in treatment comparisons. Recent Results Cancer Res. 1988;111:95–98
  8. Byar DP. Problems with using observational databases to compare treatments. Stat. Med. 1991;10:663–666
  9. Chick J, Anton R, Checinski K, Croop R, Drummond DC, Farmer R, et al. A multicentre, randomized, double-blind, placebo-controlled trial of naltrexone in the treatment of alcohol dependence or abuse. Alcohol Alcohol. 2000;35(6):587–593
  10. Collins LM, Murphy SA, Bierman KA. A conceptual framework for adaptive preventive interventions. Prev. Sci. 2004;5:185–196
  11. Collins LM, Murphy SA, Nair V, Strecher V. A strategy for optimizing and evaluating behavioral interventions. Ann. Behav. Med. 2005;30:65–73
  12. Donovan DM. Continuing care: promoting the maintenance of change. In:  Miller WR,  Heather N editor. Treating Addictive Behaviors. second ed.. New York: Plenum; 1998;p. 317–336
  13. Green SB, Byar DP. Using observational data from registries to compare treatments: the fallacy of omnimetrics. Stat. Med. 1984;3:361–370
  14. Hser YI, Anglin MD, Grella C, Longshore D, Prendergast ML. Drug treatment careers: a conceptual framework and existing research findings. J. Subst. Abuse Treat. 1997;14(6):543–558
  15. ICH (International conference on harmonization of technical requirements for registration of pharmaceuticals for human use) AT ICH harmonized tripartite guideline: statistical principles for clinical trials . Stat. Med. 1999;18:1905–1942
  16. Kidorf M, Neufeld K, Brooner RK. Combining stepped care approaches with behavioral reinforcement to motivate employment in opioid-dependent outpatients. Subst. Use Misuse. 2004;39(13–14):2215–2238
  17. Lavori PW, Dawson R. A design for testing clinical strategies: biased individually tailored within-subject randomization. J. R. Stat. Soc. Ser. A Stat. Soc. 2000;163:29–38
  18. Lavori PW, Dawson R, Rush AJ. Flexible treatment strategies in chronic disease: clinical and research implications. Biol. Psychiatry. 2000;48:605–614
  19. Lavori PW, Rush AJ, Wisniewski SR, Alpert J, Fava M, Kupfer DJ, et al. Strengthening clinical effectiveness trials: equipoise-stratified randomization. Biol. Psychiatry. 2001;50(10):792–801
  20. Lavori PW, Dawson R. Dynamic treatment regimes: practical design considerations. Clin. Trials. 2004;1(1):9–20
  21. Lunceford J, Davidian M, Tsiatis AA. Estimation of the survival distribution of treatment regimes in two-stage randomization designs in clinical trials. Biometrics. 2002;58:48–57
  22. McKay JR, Lynch KG, Shepard DS, Ratichek S, Morrison R, Koppenhaver J, et al. The effectiveness of telephone-based continuing care in the clinical management of alcohol and cocaine use disorders: 12-month outcomes. J. Consult. Clin. Psychol. 2004;72(6):967–979
  23. McLellan AT. Editorial: have we evaluated addiction treatment correctly? Implications from a chronic care perspective. Addiction. 2002;97:249–252
  24. McLellan AT, Lewis DC, O’Brien CP, Kleber HD. Drug dependence, a chronic medical illness: Implications for treatment, insurance, and outcomes evaluation. JAMA. 2000;284:1689–1695
  25. Mee-Lee D, Gartner L, Miller MM, Shulman GD. Patient Placement Criteria for the Treatment of Substance-Related Disorders. second Ed.. Chevy Chase, MD: ASAM PPC-2; 1996;
  26. In:  Miller WR editors. COMBINE Monograph Series. Combined Behavioral Intervention Manual: A Clinical Research Guide for Therapists Treating People With Alcohol Abuse and Dependence. DHHS Publication No. (NIH) 04-5288. vol. 1:Bethesda, MD: NIAAA; 2004;
  27. Murphy SA, van der Laan MJ, Robins JM CPPRG. Marginal mean models for dynamic regimes. J. Am. Stat. Assoc. 2001;96:1410–1423
  28. Murphy SA. Optimal dynamic treatment regimes. J. R. Stat. Soc. Ser. B Methodol. 2003;65(2):331–366
  29. Murphy SA. An experimental design for the development of adaptive treatment strategies. Stat. Med. 2005;24:1455–1481
  30. Murphy, S.A., Oslin, D.W., Rush, A.J., Zhu, J. For MCATS. Methodological challenges in construction effective treatment sequences for chronic disorders. Neuropsychopharmacology, in press.
  31. Oslin DW, Sayers S, Ross J, Kane V, Ten Have T, Conigliaro J, et al. Disease management for depression and at-risk drinking via telephone in an older population of veterans. Psychosom. Med. 2003;65(6):931–937
  32. O’Brien CP, McLellan AT. Myths about the treatment of addiction. Lancet. 1996;347:237–240
  33. Pettinati HM, Volpicelli JR, Pierce JD, O’Brien CP. Improving naltrexone response: an intervention for medical practitioners to enhance medication compliance in alcohol dependent patients. J. Addict Dis. 2000;19(1):71–83
  34. Pettinati HM, Weiss RD, Miller WR, Donovan D, Ernst DB, Rounsaville BJ. COMBINE Monograph Series. Medical Management Treatment Manual: A Clinical Research Guide for Medically Trained Clinicians Providing Pharmacotherapy as Part of the Treatment for Alcohol Dependence. DHHS Publication No. (NIH) 04-5289. vol. 2. Bethesda, MD: NIAAA; 2004;
  35. Pineau, J., Ghizaru, A., Gendron-Bellemare, M., Rush, A.J., Murphy, S.A. Improving the management of chronic disorders by learning adaptive treatment strategies, submitted for publication.
  36. Robins JM. Optimal structural nested models for optimal sequential decisions. In:  Lin DY,  Haegerty P editor. Proceedings of the Second Seattle Symposium on Biostatistics. New York: Springer Verlag; 2004;p. 189–326
  37. Rochon J. Issues in adjusting for covariates arising postrandomization in clinical trials. Drug Inf. J. 1999;33:1219–1228
  38. Rush AJ, Crismon ML, Kashner TM, Toprac MG, Carmody TJ, Trivedi MH, et al. Texas medication algorithm project, phase 3 (TMAP-3): rationale and study design. J. Clin. Psychiatry. 2003;64(4):357–369
  39. Schneider LS, Tariot PN, Lyketsos CG, Dagerman KS, Davis KL, Davis S, et al. National Institute of Mental Health clinical antipsychotic trials of intervention effectiveness (CATIE). Am. J. Geriatr. Psychiatry. 2001;9(4):346–360
  40. Sobell MB, Sobell LC. Stepped care as a heuristic approach to the treatment of alcohol problems. J. Consult Clin. Psychol. 2000;68(4):573–579
  41. TenHave TR, Coyne J, Salzer M, Katz I. Research to improve the quality of care for depression: alternatives to the simple randomized clinical trial. Gen. Hosp. Psychiatry. 2003;25:115–123
  42. Thall PF, Millikan RE, Sung HG. Evaluating multiple treatment courses in clinical trials. Stat. Med. 2000;19:1011–1028

PII: S0376-8716(06)00338-3

doi: 10.1016/j.drugalcdep.2006.09.008

Drug and Alcohol Dependence
Volume 88 , Pages S24-S30 , May 2007