Residual effects of intranasal methamphetamine on sleep, mood, and performance

Perez, Audrey Y.; Kirkpatrick, Matthew G.; Gunderson, Erik W.; Marrone, Gina; Silver, Rae; Foltin, Richard W.; Hart, Carl L.

doi:10.1016/j.drugalcdep.2007.10.011

« Previous Next »Drug and Alcohol Dependence
Volume 94, Issue 1 , Pages 258-262, 1 April 2008

Residual effects of intranasal methamphetamine on sleep, mood, and performance

Audrey Y. Perez
- Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
Matthew G. Kirkpatrick
- Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
- Department of Psychology, Columbia University, New York, NY 10027, USA
Erik W. Gunderson
- Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
Gina Marrone
- Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
- Department of Psychology, Barnard College of Columbia University, New York, NY 10027, USA
Rae Silver
- Department of Psychology, Columbia University, New York, NY 10027, USA
- Department of Psychology, Barnard College of Columbia University, New York, NY 10027, USA
- Department of Anatomy and Cell Biology, Columbia University, New York, NY 10027, USA
Richard W. Foltin
- Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
Carl L. Hart
- Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
- Department of Psychology, Columbia University, New York, NY 10027, USA
- Corresponding author at: Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA. Tel.: +1 212 543 5884; fax: +1 212 543 5991.

Received 31 August 2007; received in revised form 19 October 2007; accepted 24 October 2007.

Abstract

Although intranasal methamphetamine abuse has increased, there are no published data investigating the residual effects of the drug under controlled conditions. Thus, the current study examined the residual effects of single-dose intranasal methamphetamine administration on a broad range of behavioral and physiological measures. Non-treatment seeking methamphetamine abusers (n=11) completed this two-week, in patient, within-participant, double-blind study. The study consisted of four two-day blocks of sessions; each block was separated by at least 48h. At approximately 10:00h, on the first day of each block, participants received one of four intranasal methamphetamine doses (0, 12, 25, 50mg/70kg). Lights were turned out at 23:00h that evening and sleep measures were assessed. On the morning of the second day of each block, methamphetamine plasma levels, cardiovascular measures, mood, subjective reports of the previous evening's sleep, and psychomotor performance were assessed to determine residual drug effects. The larger methamphetamine doses (25 and 50mg) markedly disrupted subjective measures of that night's sleep and some indices of next-day mood, but only the largest dose (50mg) dose decreased objective measures of that night's sleep and increased next-day physiological measures. Methamphetamine did not produce any negative residual effects on early next-day performance. Future studies should assess methamphetamine-related residual effects following repeated doses administered over consecutive days.