Drug and Alcohol Dependence
Volume 108, Issue 1 , Pages 70-76 , 1 April 2010

Association of polymorphisms of the serotonergic system with smoking initiation in Caucasians

  • Maria Iordanidou

      Affiliations

    • Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Dragana Campus, Alexandroupolis 68100, Greece
  • ,
  • Anna Tavridou

      Affiliations

    • Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Dragana Campus, Alexandroupolis 68100, Greece
  • ,
  • Ioannis Petridis

      Affiliations

    • Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Dragana Campus, Alexandroupolis 68100, Greece
    • Department of Internal Medicine, Academic General Hospital of Alexandroupolis, Alexandroupolis 68100, Greece
  • ,
  • Soultana Kyroglou

      Affiliations

    • Department of Internal Medicine, Academic General Hospital of Alexandroupolis, Alexandroupolis 68100, Greece
  • ,
  • Loukas Kaklamanis

      Affiliations

    • Department of Pathology, Onassis Cardiac Surgery Center, Athens 17674, Greece
  • ,
  • Dimitrios Christakidis

      Affiliations

    • Department of Internal Medicine, Academic General Hospital of Alexandroupolis, Alexandroupolis 68100, Greece
  • ,
  • Vangelis G. Manolopoulos

      Affiliations

    • Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Dragana Campus, Alexandroupolis 68100, Greece
    • Corresponding Author InformationCorresponding author. Tel.: +30 2551 030523; fax: +30 2551 030523.

Received 7 July 2009 ,Revised 31 October 2009 ,Accepted 17 November 2009.

References 

  1. Audrain J, Lerman C, Gomez-Caminero A, Boyd NR, Orleans CT. The role of trait anxiety in nicotine dependence. J. Appl. Biobehav. Res. 1998;3:29–42
  2. Buckland PR, Hoogendoorn B, Guy CA, Smith SK, Coleman SL, O’Donovan MC. Low gene expression conferred by association of an allele of the 5-HT2C receptor gene with antipsychotic-induced weight gain. Am. J. Psychiatry. 2005;163:613–615
  3. Chu SL, Xiao D, Wang C, Jing H. Association between 5-hydroxytryptamine transporter gene-linked polymorphic region and smoking behavior in Chinese males. Chin. Med. J. (Engl). 2009;122:1365–1368
  4. Collier DA, Stobber G, Li T, Heils A, Catalano M, Bella DD, et al. A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in the susceptibility to affective disorders. Mol. Psych. 1996;1:453–460
  5. Cravchik A, Goldman D. Neurochemical individuality: genetic diversity among human dopamine and serotonin receptors and transporters. Arch. Gen. Psychiatry. 2000;57:1105–1114
  6. Dani JA, Heinemann S. Molecular and cellular aspects of nicotine abuse. Neuron. 1996;16:905–908
  7. Di Matteo V, Di Giovanni G, Di Mascio M, Esposito E. SB 242084, a selective serotonin2C receptor antagonist, increases dopaminergic transmission in the mesolimbic system. Neuropharmacology. 1999;38:1195–1205
  8. Di Matteo V, Di Mascio M, Di Giovanni G, Esposito E. Acute administration of amitriptyline and mianserin increases dopamine release in the rat nucleus accumbens: possible involvement of serotonin2C receptors. Psychopharmacology. 2000;150:45–51
  9. Di Matteo V, Cacchio M, Di Giulio C, Esposito E. Role of serotonin2c receptors in the control of brain dopaminergic function. Pharmacol. Biochem. Behav. 2002;71:727–734
  10. Di Giovanni G, De Deurwaerdere P, Di Mascio M, Di Matteo V, Esposito E, Spampinato U. Selective blockade of serotonin-2C/2B receptors enhances mesolimbic and mesostratial dopaminergic function: a combined in vivo electrophysiological and microdialysis study. Neuroscience. 1999;91:587–597
  11. Gerra G, Garofano L, Saimovic A, Moi G, Branchi B, Bussandri M, et al. Association of the serotonin transporter promoter polymorphism with smoking behavior among adolescents. Am. J. Med. Genet. Part B Neuropsychiatr. Genet. 2005;135B:73–78
  12. Grottick AJ, Corrigall WA, Higgins GA. Activation of 5-HT2C receptors reduces the locomotor and rewarding effects of nicotine. Psychopharmacology. 2001;157:292–298
  13. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D, et al. Allelic variation of human serotonin transporter gene expression. J. Neurochem. 1996;66:2621–2624
  14. Henningfield JE, Fant RV. Tobacco use as drug addiction: the scientific foundation. Nicotine Tob. Res. 1999;1(Suppl 2):S31–35
  15. Hill MJ, Reynolds GP. 5-HT2c receptor gene polymorphisms associated with antipsychotic drug action alter promoter activity. Brain Res. 2007;1149:14–17
  16. Ho MK, Tyndale RF. Overview of the pharmacogenomics of cigarette smoking. Pharmacogenom. J. 2007;7:81–98
  17. Hu S, Brody CL, Fisher C, Gunzerath L, Nelson ML, Sabol SZ, et al. Interaction between the serotonin transporter gene and neuroticism in cigarette smoking behavior. Mol. Psychiatry. 2000;5:181–188
  18. Iordanidou M, Tavridou A, Vasiliadis MV, Arvanitidis KI, Petridis J, Christakidis D, et al. The −759C/T polymorphism of the 5-HT2C receptor is associated with type 2 diabetes in male and female Caucasians. Pharmacogen. Genom. 2008;18:153–159
  19. Ishikawa H, Ohtsuki T, Ishiguro H, Yamakawa-Kobayashi K, Endo K, Lin YL, et al. Association between serotonin transporter gene polymorphism and smoking among Japanese males. Cancer Epidemiol. Biomark. Prev. 1999;8:831–833
  20. Kaiser R, Tremblay PB, Roots I, Brockmoller J. Validity of PCR with emphasis on variable number of tandem repeat analysis. Clin. Biochem. 2002;35:49–56
  21. Kremer I, Bacher-Melman R, Reshef A, Broude L, Nemanov L, Gritsenko I, et al. Association of the serotonin transporter gene with smoking behavior. Am. J. Psychiatry. 2005;162:924–930
  22. Lerer E, Kanyas K, Karni O, Ebstein RP, Lerer B. Why do young women smoke? II. Role of traumatic life experience, psychological characteristics and serotonergic genes. Mol. Psychiatry. 2006;11:771–781
  23. Lerman C, Shields PG, Audrain J, Main D, Cobb B, Boyd NR, et al. The role of serotonin transporter gene in cigarette smoking. Cancer Epidemiol. Biomark. Prev. 1998;7:253–255
  24. Lerman C, Caporaso NE, Audrain J, Main D, Boyd NR, Shields PG. Interacting effects of the serotonin transporter gene and neuroticism in smoking practices and nicotine dependence. Mol. Psychiatry. 2000;5:189–192
  25. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 1996;274:527–531
  26. Li MD, Cheng R, Ma JZ, Swan GE. A meta-analysis of estimated genetic and environmental effects on smoking behavior in male and female adults twins. Addiction. 2003;98:23–31
  27. Meyer J, Saam W, Mossner R, Cangir O, Ortega GR, Tatschner T. Evolutionary conserved microsatellites in the promoter region of the 5-hytroxytryptamine receptor 2C gene (HTR2C) are not associated with bipolar disorder in females. J. Neural. Transm. 2002;109:939–946
  28. Mihailescu S, Palomero-Rivero M, Meade-Huerta P, Maza-Flores A, Drucker-Colin R. Effects of nicotine and mecamylamine on rat dorsal raphe neurons. Eur. J. Pharmacol. 1998;360:31–36
  29. Munafo MR, Clark T, Johnstone EC, Walton RT. The genetic basis for smoking behavior: A systematic review and meta-analysis. Nicotine Tob. Res. 2004;6:583–597
  30. Pinsonneault J, Sadee W. Pharmacogenomics of multigenic diseases: sex-specific differences in disease and treatment outcome. AAPS Pharm. Sci. 2003;5:5:E29
  31. Pompeiano M, Palacios JM, Mengod G. Distribution of the serotonin 5-HT2C receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors. Brain Res. Mol. Brain Res. 1994;23:163–178
  32. Rasmussen H, Bagger Y, Tanko LB, Christiansen C, Werge T. Lack of association of the serotonin transporter gene promoter region polymorphism, 5-HTTLPR, including rs25531 with cigarette smoking and alcohol consumption. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009;150B:575–580
  33. Reynolds GP, Yao ZJ, Zhang XB, Sun J, Zhang ZJ. Pharmacogenetics of treatment in first-episode schizophrenia: D3 and 5-HT2C receptor polymorphism separately associate with positive and negative symptom response. Eur. Neuropsychopharmacol. 2005;15:143–151
  34. Ribeiro EB, Bettiker RL, Bogdanov M, Wurtman RJ. Effects of systemic nicotine on serotonin release in rat brain. Brain Res. 1993;621:311–318
  35. Shih JC, Zhu Q, Chen K. Determination of transcription initiation sites and promoter activity of the human 5-HT2A receptor gene. Behav. Brain Res. 1996;73:59–62
  36. Sieminska A, Buczkowski K, Jassem E, Tkacz E. Lack of association between serotonin transporter gene polymorphism 5-HTTLPR and smoking among polish population: a case-control study. BMC Med. Genet. 2008;9:76–83
  37. Smeraldi E, Serretti A, Artioli P, Lorenzi C, Catalano M. Serotonin-transporter gene-linked polymorphic region: possible pharmacogenetic implications of rare variants. Psychiatr. Gen. 2006;16:153–158
  38. Stam NJ, Vanderheyden P, van Alebeek C, Klomp J, de Boer T, van Delft AM, et al. Genomic organisation and functional expression of the gene encoding the human serotonin 5-HT2C receptor. Eur. J. Pharmacol. 1994;269:339–348
  39. Trummer O, Koppel H, Wacher TC, Grunbacher G, Gutjahr M, Stanger O, et al. The serotonin transporter gene is not associated with smoking behavior. Pharmacogenomics J. 2006;6:397–400
  40. Vink JM, Smit AB, de Geus EJ, Sullivan P, Willemsen G, Hottenga JJ, et al. Genome-wide association study of smoking initiation and current smoking. Am. J. Hum. Genet. 2009;84:367–379
  41. Yonan AL, Palmer AA, Gilliam TC. Hardy–Weinberg disequilibrium identified genotyping error of the serotonin transporter (SLC6A4) promoter polymorphism. Psychiatr. Gen. 2006;16:31–34
  42. Yuan X, Yamada K, Ishiyama-Shigemoto S, Koyama W, Nonaka K. Identification of polymorphic loci in the promoter region of the serotonin 5-HT2C receptor gene and their association with obesity and type II diabetes. Diabetologia. 2000;43:373–376
  43. White KJ, Walline CC, Barker EL. Serotonin transporters: implications for antidepressant drug development. AAPS J. 2005;7:421–433

PII: S0376-8716(09)00424-4

doi: 10.1016/j.drugalcdep.2009.11.015

Drug and Alcohol Dependence
Volume 108, Issue 1 , Pages 70-76 , 1 April 2010