Elsevier

Drug and Alcohol Dependence

Volume 167, 1 October 2016, Pages 228-232
Drug and Alcohol Dependence

Short communication
Evaluation of a reduced nicotine product standard: Moderating effects of and impact on cannabis use

https://doi.org/10.1016/j.drugalcdep.2016.08.620Get rights and content

Highlights

  • Cannabis users and non-users differed on demographic and smoking characteristics.

  • Cannabis use did not moderate most effects of very low nicotine content cigarettes.

  • Very low nicotine content cigarette use did not significantly impact cannabis use.

Abstract

Introduction

The Family Smoking Prevention and Tobacco Control Act authorized the FDA to reduce the nicotine content in cigarettes. Research is needed to guide proposed regulations, including evaluation of consequences to public health. This study evaluated how a reduced nicotine product standard might be moderated by and impact cannabis use.

Methods

Secondary analysis of a controlled clinical trial examining the effects of nicotine content in cigarettes in adult daily smokers. Linear regression assessed whether baseline cannabis use moderated behavioral, subjective, or physiological effects of smoking very low nicotine content (VLNC) versus normal nicotine content (NNC) cigarettes. Repeated measures analysis of associations between nicotine condition and prevalence and frequency of cannabis use was completed using generalized estimating equations (GEE).

Results

Cannabis use did not moderate most of the following effects of VLNC cigarettes: Among cannabis users and non-users, smokers randomized to VLNC cigarettes reported lower nicotine dependence, cigarettes per day, biomarkers of nicotine exposure, and craving compared to smokers randomized to NNC cigarettes. Non-cannabis using smokers randomized to VLNC cigarettes also reported lower smoking dependence motives and had lower tobacco-specific nitrosamine exposure and total puff volume versus smokers randomized to NNC cigarettes. For cannabis users, smokers randomized to VLNC cigarettes reported decreased positive affect. VLNC cigarette use did not impact the prevalence or frequency of cannabis use.

Discussion

Findings provide evidence that nicotine reduction in cigarettes could have beneficial effects on cigarette smoking regardless of cannabis use. Results suggest that transitioning to VLNC cigarettes is unlikely to alter current rates of cannabis use.

Introduction

The Family Smoking Prevention and Tobacco Control Act (FSPTCA; US Congress, 2009) granted the Food and Drug Administration (FDA) the authority to enact product standards that reduce the nicotine content in cigarettes. This reduction is congruent with the hypothesis that reducing the nicotine in cigarettes to a level below an addiction threshold should no longer support dependence, and reduce the public health burden of tobacco (Benowitz and Henningfield, 1994, Benowitz and Henningfield, 2013).

In a 6-week randomized multisite trial (Donny et al., 2015), participants assigned to smoke cigarettes with a nicotine content of 2.4 mg per g of tobacco or lower reported smoking fewer cigarettes per day (CPD) and had decreased biomarkers of nicotine exposure relative to participants who smoked cigarettes with normal nicotine content (NNC; i.e., 15.8 mg/g). Though these findings indicate that VLNC cigarettes may have a positive impact on smokers generally, it remains unknown how reduced nicotine standards would impact smokers who also use cannabis.

Cannabis is the most widely used illicit drug globally; as of 2012, 10.2% and 2.1% of the U.S. population were non-daily and daily users, respectively (Pacek et al., 2015). Cannabis and tobacco are commonly used concurrently: most cannabis users smoke tobacco, and up to half of tobacco smokers use cannabis (Peters et al., 2012). In addition to concurrent use, there is evidence for these substances substituting for one another. Some co-users report increasing tobacco use to cope with withdrawal during cannabis abstinence (Allsop et al., 2014, Levin et al., 2010). Preclinical evidence indicates that THC may reduce nicotine withdrawal (Balerio et al., 2004), suggesting a negative reinforcement pathway that would promote cannabis use during tobacco abstinence. Thus, cannabis users may be differentially impacted by the effects of nicotine reduction on smoking, and reducing nicotine in cigarettes may impact cannabis use.

The present study examines how: (1) baseline cannabis use impacts responses to VLNC cigarettes; and (2) use of VLNC cigarettes impacts cannabis use. We hypothesized that cannabis users would smoke more CPD and experience more withdrawal and craving as a consequence of nicotine reduction. We hypothesized that participants assigned to VLNC cigarettes would be more likely to report cannabis use, and to report using cannabis on a greater proportion of days, as compared to participants assigned to NNC cigarettes, to compensate for the lower nicotine content and manage withdrawal symptoms.

Section snippets

Participants

Eligible participants (N = 839) were adult, daily smokers who: smoked ≥5 CPD, had expired carbon monoxide (CO) >8 ppm or urine cotinine >100 ng/ml; did not intend to quit smoking in next 30 days, regularly use other tobacco products or binge drink (i.e., >9 of past 30 days), have unstable medical/psychiatric conditions, positive illicit drug toxicology screen other than cannabis, exclusively use “roll your own” cigarettes, and were not pregnant/breastfeeding.

Procedure

Methods for the 7-arm, double-blind, 10-site,

Baseline characteristics of cannabis users versus non-users

At baseline, 28.9% participants were current cannabis users. Of these, 71.5% reported cannabis use and tested positive for THC; 16.4% reported use but tested negative for THC; 12.1% tested positive for THC but did not report use. Current cannabis users self-reported using cannabis on an average of 11.3 days/past month (SD = 11.7). Relative to non- users, cannabis users were more likely to be male χ2 (1, N = 717) = 8.8, p = 0.003; Caucasian χ2 (2, N = 717) = 8.0, p = 0.018; younger t(715) = 10.2, p < 0.001; had

Discussion

Findings indicate that effects of smoking VLNC cigarettes in cannabis users are largely similar to those in non-cannabis users. Cannabis users and non-users experienced reductions in CPD, nicotine dependence, craving, and TNEs. Though differences between cannabis and non-cannabis users were observed on the WISDM, PANAS, and smoking topography during the experimental cigarette period, the lack of significant interactions indicate that baseline cannabis use did not moderate the effect of VLNC

Role of the funding source

Research reported in this publication was supported by the National Institute on Drug Abuse and FDA Center for Tobacco Products (U54 DA031659). Salary support for LRP during the preparation of this paper was provided by T32DA0079209 and T32AI007329. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or the Food and Drug Administration. Portions of these data were presented at the College on Problems of Drug Dependence 2015

Conflict of interest

Dr. Drobes reports other support from law firms (on behalf of individual plaintiffs) outside the submitted work, while Dr. McClernon reports previous grant support from Pfizer, Inc., outside the submitted work. Dr. Vandrey reports being a consultant for Zynerba Pharmaceutials outside the submitted work. The authors have no other conflicts of interest to declare.

Contributors

Authors Pacek and Vandrey conceptualized the research question Authors Pacek, Bangdiwala, and Koopmeiners conducted the statistical analyses. Author Pacek wrote the first draft of the manuscript. All authors contributed to, have critically reviewed and revised, and have approved of the final manuscript.

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