Drug and Alcohol Dependence
Volume 58, Issue 1 , Pages 77-83, 1 February 2000

The role of stimulated lipid peroxidation and impaired calcium sequestration in the enhancement of cocaine induced hepatotoxicity by ethanol

  • Serdar Öztezcan

      Affiliations

    • Department of Biochemistry, Medical Faculty of Istanbul, University of Istanbul, Çapa, 34390 Istanbul, Turkey
    • Corresponding Author InformationCorresponding author. Tel.: +90-212-6311323
    • ,
  • Semra Doğru-Abbasoğlu

      Affiliations

    • Department of Biochemistry, Medical Faculty of Istanbul, University of Istanbul, Çapa, 34390 Istanbul, Turkey
    • ,
  • Ümit Mutlu-Türkoğlu

      Affiliations

    • Department of Biochemistry, Medical Faculty of Istanbul, University of Istanbul, Çapa, 34390 Istanbul, Turkey
    • ,
  • Zerrin Calay

      Affiliations

    • Department of Pathology, Medical Faculty of Cerrahpaşa, University of Istanbul, Istanbul, Turkey
    • ,
  • Gülçin Aykaç-Toker

      Affiliations

    • Department of Biochemistry, Medical Faculty of Istanbul, University of Istanbul, Çapa, 34390 Istanbul, Turkey
    • ,
  • Müjdat Uysal

      Affiliations

    • Department of Biochemistry, Medical Faculty of Istanbul, University of Istanbul, Çapa, 34390 Istanbul, Turkey

Received 19 March 1999; received in revised form 7 May 1999; accepted 4 June 1999.

Abstract 

The purpose of this study was to investigate possible mechanism of cocaine-induced hepatotoxicity and its potentiation by ethanol in mice. Ethanol (2 g/kg) and/or cocaine (25 mg/kg) injections were given as binge model (five injections in 3 days). Cocaine administration with or without ethanol caused an increase in lipid peroxidation in liver homogenate and its subcellular fractions. The greatest increases were observed in mitochondrial fraction following cocaine plus ethanol treatment. Also, glutathione (GSH) levels were increased in liver homogenate and its mitochondrial fractions after cocaine and cocaine plus ethanol treatment. Microsomal calcium sequestration was found to decrease in all treatments. These results suggest that increased lipid peroxidation and decreased microsomal calcium sequestration in the liver may play a possible role cocaine-induced hepatotoxicity and its potentiation by ethanol.

Keywords: Calcium sequestration, Cocaine, Ethanol, Hepatotoxicity, Lipid peroxidation

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PII: S0376-8716(99)00061-7

Drug and Alcohol Dependence
Volume 58, Issue 1 , Pages 77-83, 1 February 2000

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