Review paperA comparison of the catecholamine releasing effect of the khat alkaloids (−)-cathinone and (+)-norpseudoephedrine☆
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Khat (Catha edulis F.) and cannabinoids: Parallel and contrasting behavioral effects in preclinical and clinical studies
2015, Pharmacology Biochemistry and BehaviorCitation Excerpt :Khat chewing has been described as ‘pleasurable’ and the behavior of repetitive chewing of khat leaves has been labeled as from of ‘psychic dependence’, characterized by compulsive khat consumption. Self-administration studies using (−) cathinone have illustrated the role of this alkaloid as a dependence producing compound among the khat alkaloids enhancing the behavior of animals that gives them access to the substance (Kalix, 1983). Johanson and Schuster (1981) have reported that intravenous infusions of cathinone will maintain responding in rhesus monkeys, which had been previously trained to lever press for cocaine injections.
Direct effect of khat and garlic extracts on blood lipids contents: Preliminary in vitro study
2010, Obesity Research and Clinical PracticeCitation Excerpt :In addition, for combination formulations such as KG11, KG12 and KG21, the decrease in triglyceride were much enhanced to about 47–60%. Khat has been used for centuries to alleviate the sensation of hunger [38,39]. Anorexia is a consequence of chewing khat leaves [4,40].
A review of the neuropharmacological properties of khat
2008, Progress in Neuro-Psychopharmacology and Biological PsychiatryThe pharmacology of psychoactive alkaloids from Ephedra and Catha
1991, Journal of EthnopharmacologyDiscriminative stimulus properties of (+)cathine, an alkaloid of the khat plant
1990, Pharmacology, Biochemistry and Behavior
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A preliminary account of this report has been given at the 33rd International Congress on Alcoholism and Drug Dependence, Tangiers, October 1982, and at the International Conference on Khat, Antananarivo, January 1983.